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Innovative stem cell treatment at NUH

The doctors from National University Hospital (NUH) performed fetal stem cell transplants to a 4-year-old Taiwanese girl that was suffering from a bone disease.

She is now doing much better after enduring the effects of Osteogeneis imperfecta (OI), or brittle-bone disease, as a baby.

The team of experts from the National University Hospital treated the little girl with bone forming stem cells and connective tissue cells that can form and improve bone tissue. This was possible due to collaboration between Singapore, Taiwan and Sweden.

The treatment started when the girl was 31-week-old fetus, in 2008 and another injection was administrated when she was 1 year old.

Thanks to this treatment she is now a healthy active child, able to take part in various sporting activities. The same treatment was received by a boy in Sweden, in 2005. They both had excellent results.

20,000 children worldwide are affected by Osteogeneis imperfecta and often lead to severe bone damage and numerous fractures. The team conducted the research and administered the stem cell treatment over a span of five years was led by Professor Mahesh Choolani, Associate Professor and Senior Consultant of Department of Obstetrics & Gynaecology. “We are extremely heartened by the results of this transplant and are proud to have been part of this effort to develop a potential new treatment method for OI,” said Prof Choolani.